Abcam, ab79785, Anti-NUP88 antibody

Size: 100µg
Rabbit Polyclonal NUP88 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Mar 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NUP88 protein is also known as nucleoporin 88. It is a component of the nuclear pore complex weighing approximately 88 kDa. This protein plays a major role in regulating the exchange of materials between the nucleus and the cytoplasm. NUP88 is expressed in various tissues throughout the human body with higher expression seen in rapidly dividing cells. It functions within the nucleocytoplasmic transport system facilitating the movement of molecules like RNA and proteins.
Biological function summary
NUP88 serves as an important component of the nuclear pore complex which is responsible for maintaining communication between the nucleus and cytoplasm. The protein forms part of an extensive network known as the nuclear pore complex allowing regulated transport. NUP88 interacts closely with other nucleoporins such as NUP214 to maintain the structural integrity of the nuclear pore and ensure proper cellular function. It has been implicated in the transport of specific cargo molecules that maintain homeostasis within the cell.
Pathways
NUP88 engages in the nuclear transport pathway playing a critical role in the direction of nuclear import and export processes. This pathway is essential for proper gene expression and cell cycle regulation. In the context of nuclear transport NUP88 works with proteins like importins and exportins to facilitate the movement of signaling molecules that drive these processes. Another significant pathway involving NUP88 is the immune response pathway where it helps mediate the transport of interferon-induced proteins.
Elevated levels of NUP88 have been associated with several types of cancer including colorectal and breast cancer. This association suggests a potential role in tumor progression. During tumorigenesis interactions between NUP88 and proteins such as NUP214 can become dysregulated leading to compromised nuclear-cytoplasmic transport. High expression of NUP88 has also been linked to neurodegenerative disorders where it may contribute to the pathogenesis through altered nuclear pore function or impaired transport of critical neuronal proteins.