Abcam, ab80194, Anti-Transferrin Receptor 2/TFR2 antibody

Size: 100µg
Rabbit Polyclonal Transferrin Receptor 2/TFR2 antibody. Suitable for IHC-P, IHC-Fr, WB and reacts with Human, Mouse, Rat samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:IHC-P, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Transferrin Receptor 2 (TFR2) is a protein that facilitates iron uptake by binding to transferrin which is an iron-carrier protein in the blood. Also known as TFRC2 or CD71L2 it is a transmembrane glycoprotein with a molecular mass around 90 kDa. TFR2 is mainly expressed in the liver and erythroid cell precursors. It plays an important role in maintaining cellular iron homeostasis by mediating the endocytosis of transferrin-bound iron. Its expression can vary depending on the body’s iron levels and cellular type.
Biological function summary
TFR2 operates as an iron sensor and regulator influencing hepcidin expression a hormone critical for iron homeostasis. TFR2 is not part of any specific complex but interacts with several proteins such as HFE and TFR1 in iron sensing. It helps communicate the body’s iron status to the liver for the modulation of hepcidin levels. This balance ensures the regulation of systemic iron uptake and release which is essential for various physiological processes like erythropoiesis.
Pathways
TFR2 is involved prominently in the iron homeostasis pathway and the erythropoiesis pathway. In the iron homeostasis pathway it works alongside hepcidin to monitor and regulate iron levels in the body. The role it plays in erythropoiesis relates to its interaction with other iron-related proteins like TFR1 where it contributes to iron delivery necessary for red blood cell production. These pathways illustrate TFR2's importance in not only iron uptake but also the overall iron regulatory processes that sustain body function.
Defects or mutations in TFR2 are connected to hereditary hemochromatosis which causes iron overload in tissues. Aberrant TFR2 function can disrupt the normal regulation of hepcidin leading to this iron accumulation. It also plays a role in anemia of chronic disease due to its influence on erythropoiesis through interactions with HFE and TFR1. These associations highlight the critical importance of TFR2 in both maintaining iron equilibrium and implicating it in iron-related pathologies.