Abcam, ab8049, Anti-Synaptophysin antibody [SY38] - Synaptic Marker

Size: 500µL
Anti-Synaptophysin antibody [SY38] (ab8049) is a mouse monoclonal antibody detecting Synaptophysin in Western Blot, Flow Cytometry, IHC-P, IHC-Fr, ICC/IF . Suitable for Cow, Hamster, Human, Mouse, Rat . - Over 220 publications - Trusted since 2001
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SY38,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Cow, Hamster,
Applications:WB, IHC-Fr, ICC/IF, IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human SYP.P08247

Product details:
Product Specifications
Anti-Synaptophysin antibody [SY38] (ab8049) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB in cow, hamster, human, mouse, rat samples.
Anti-Synaptophysin antibody [SY38] (ab8049) specifically detects Synaptophysin (UniProt ID: P20488; Molecular weight: 34kDa) and is sold in 500 µL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-Synaptophysin antibody [SY38] (ab8049) has high sensitivity and specificity.
Anti-Synaptophysin antibody [SY38] (ab8049) has been cited over 228 times in peer reviewed journals and is trusted by the scientific community.
Anti-Synaptophysin antibody [SY38] (ab8049) has 15 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.3Preservative: 0.09% Sodium azideConstituents: PBS, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptophysin also known as SYP is a glycoprotein approximately 38 kDa in size. It is expressed abundantly in the presynaptic vesicle membranes of neurons and in neuroendocrine cells. Synaptophysin serves as a marker for synaptic vesicles and neuroendocrine tumors. The protein plays a significant role in synaptic vesicle cycling processes engaging in the release and recycling of neurotransmitters.
Biological function summary
Synaptophysin contributes to synaptic transmission and is engaged in the formation and maintenance of the synaptic vesicle pools. It is a part of the complex involved in neuronal communication and might interact with other vesicular proteins to ensure efficient neurotransmitter exchange. Researchers often utilize anti-Synaptophysin antibodies such as Alexa Fluor 647 labeled ones for visualization under confocal microscopy.
Pathways
Synaptophysin operates within pathways involving neurotransmitter release and synaptic vesicle cycle. It connects to proteins like Synaptotagmin and SNAP-25 integral to the facilitation of synaptic transmission and exocytosis. These pathways ensure efficient signal conduction across neurons which is critical for normal nervous system functioning.
Synaptophysin shows a strong association with neurodegenerative diseases and certain cancers like neuroblastoma. Altered expression levels or dysfunction of Synaptophysin can serve as a diagnostic marker for these conditions. The protein is connected with proteins like Bcl-2 in neurodegenerative diseases affecting cell survival and apoptosis pathways.