Abcam, ab81292, Anti-ATM (phospho S1981) antibody [EP1890Y]

Size: 20µL / 100µL / 1mL
Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) is a rabbit monoclonal antibody detecting ATM in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, Dot Blot . Suitable for Human . - Biophysical QC for unrivalled batch-batch consistency - Over 320 publications - Trusted since 2009
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1890Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Dot, IHC-P, IP, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, Flow Cyt (Intra), IHC-P, IP, WB in human samples.
Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) has been cited over 328 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) has 17 independent reviews from customers.
Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) specifically detects ATM Phospho-S1981 (UniProt ID: Q13315; Molecular weight: 351kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EP1890Y -
ab208775
Antibody clone EP1890Y is also available pre-conjugated to a variety of labels for your convenience - PE, APC, HRP, Alkaline Phosphatase, Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 555 (
ab305629
ab305630
ab305631
ab308654
ab309629
ab309995
ab310358
ab311880
ATM is a significant target in oncology due to its role in DNA repair and maintaining genomic stability. Mutations in the ATM gene can lead to defective DNA repair, resulting in increased cancer risk and chemotherapy resistance.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATM also known as Ataxia Telangiectasia Mutated is a protein kinase with a molecular weight of approximately 370 kDa. ATM protein primarily resides in the cell nucleus and functions as a critical regulator of the cell cycle. It plays a significant role in the detection of DNA damage and initiation of repair processes. As part of its mechanical functions ATM phosphorylates serine and threonine residues on various substrates most notably in response to double-strand breaks in DNA. This activity is important for maintaining genomic stability.
Biological function summary
ATM acts as a coordinator in cellular response to DNA damage highly interacting with multiple components of the DNA repair machinery. It forms a complex with proteins like NBS1 and MRN complex facilitating repair by recruiting and activating other proteins involved in homologous recombination and non-homologous end joining pathways. ATM also modulates p53 activity a primary response factor in cellular stress management linking ATM to control of cell cycle arrest and apoptosis. This positions ATM as an integral part of maintaining cellular integrity in face of genomic insult.
Pathways
ATM integrates neatly within the DNA damage response and cell cycle control pathways. ATM's operative relationship with the MRN complex and its role in the PI3K-related protein kinase family helps initiate appropriate repair processes upon DNA damage detection. Additionally ATM regulates the activity of proteins such as Chk2 which further propagates signals to p53 influencing decisions between cell cycle arrest and apoptosis. These interactions link ATM closely to essential processes like DNA repair and cell survival highlighting its role in genomic maintenance.
ATM mutations or dysregulation leads to Ataxia Telangiectasia an autosomal recessive disorder characterized by neurodegeneration immune deficiencies and cancer predisposition. ATM dysfunction also connects to cancer development particularly breast cancer where it transmits signals involving BRCA1 contributing to DNA repair through homologous recombination. Understanding ATM dynamics and related pathways has important implications for developing therapeutic strategies to manage or mitigate effects associated with its dysfunction.