Abcam, ab81690, Anti-MYO18A antibody

Size: 100µL
Rabbit Polyclonal MYO18A antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MYO18A aa 2000 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MYO18A aa 2000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92614

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab81690 was affinity purified using an epitope specific to MYO18A immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MYO18A protein also known as Myosin XVIIIA is a non-conventional myosin with a molecular mass of approximately 200 kDa. This protein is involved in actin-based cellular functions and motor activities. MYO18A displays broad expression in various tissues notably in muscle and neural tissues functioning as an essential element of the cytoskeleton. It shows properties that connect it to both structural and regulatory roles within cells.
Biological function summary
Within cellular contexts MYO18A participates in cytoskeletal organization affecting cell shape and movement. This protein functions as a part of microfilament structures and associates with other proteins to form complexes contributing to cellular dynamics regulation. It modulates actin filament stability and participates in cellular protrusion and migration impacting locomotion and signaling pathways.
Pathways
MYO18A integrates into cytoskeletal and signaling networks linking it with pathways such as the Rho-signaling and MAPK pathways. It interacts with proteins like actin and possibly collaborates with Rho-associated coiled-coil-containing protein kinases (ROCK) to mediate some of its functions. MYO18A-related pathways are important for cellular dynamics and overall homeostasis influencing tissue development and repair.
Abnormalities in MYO18A have been linked to cancer and neuromuscular disorders. In oncology its expression changes may associate with tumor progression potentially interacting with other proteins like SRC kinase that affect cell adhesion and proliferation. In neuromuscular contexts MYO18A mutations or dysregulation can relate to disorders impacting muscle function and integrity aligning with proteins like dystrophin involved in muscle structure and signaling.