Abcam, ab82110, Anti-Aprotinin antibody [35]

Size: 100µg
Mouse Monoclonal Aprotinin antibody. Suitable for WB, I-ELISA and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Cow Pancreatic trypsin inhibitor.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:35,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Cow,
Applications:I-ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Cow Pancreatic trypsin inhibitor.P00974

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, 2.9% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Aprotinin is a protein that works mechanically as a serine protease inhibitor blocking the activity of enzymes like trypsin and kallikrein. Researchers know it also by the names 'bovine pancreatic trypsin inhibitor' (BPTI) or Trasylol. Aprotinin has a molecular mass of approximately 6.5 kDa. It is expressed in bovine tissue and extracted from bovine lung which allows scientists to use it in various experimental and clinical applications.
Biological function summary
Aprotinin plays a role in controlling proteolytic processes by inhibiting enzymes that degrade proteins. This inhibition is important in reducing fibrinolysis where it prevents the breakdown of fibrin clots. As a single-chain polypeptide aprotinin does not function as part of a larger protein complex but rather exerts its effects by directly interacting with target proteases in the bloodstream and other biological fluids.
Pathways
Aprotinin plays an important role in the coagulation pathway maintaining hemostasis by inhibiting fibrinolysis. It directly interacts with proteins such as plasmin which is involved in the breakdown of blood clots. Additionally aprotinin impacts kallikrein-kinin systems a second pathway it is involved with affecting blood pressure regulation and inflammation.
Aprotinin is studied in conditions involving excessive bleeding like surgery-related hemorrhage due to its potential to control bleeding by slowing clot breakdown. Researchers also examine its use in inflammatory disorders since it affects pathways involving kallikreins. Although effective there are considerations of safety when using aprotinin as it has been linked to adverse outcomes in cardiovascular-associated conditions with proteins like kallikrein and plasmin playing roles in these processes.