Abcam, ab82716, Anti-Okadaic Acid antibody [7E1]

Size: 100µL
Mouse Monoclonal Okadaic Acid antibody. Suitable for ELISA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Okadaic Acid.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:7E1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Okadaic acid acts as a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A) which play critical roles in the regulation of cellular phosphorylation states. It does not have alternate names frequently used in scientific literature. Okadaic acid is a marine-sponge-derived polyether toxin with a molecular mass of approximately 805 Da. This compound presents in the marine environment particularly in dinoflagellates and accumulates in shellfish.
Biological function summary
Okadaic acid inhibits protein phosphatases by binding directly to their catalytic subunits preventing dephosphorylation of proteins. This inhibition affects multiple cell signaling pathways causing disruptions in normal cellular processes. Okadaic acid is not typically part of a complex but interacts directly with its targets in its active form to exert its effects. It influences processes such as cell cycle progression apoptosis and inflammation making it a valuable tool for studying cellular regulation.
Pathways
Okadaic acid influences key cell signaling pathways like the Wnt signaling pathway and the cell cycle regulation pathway. In the Wnt pathway it modulates the stability of beta-catenin impacting gene expression and cell fate decisions. In cell cycle regulation okadaic acid affects the activity of cyclin-dependent kinases (CDKs) by altering their phosphorylation state thereby influencing cell division cycles.
Okadaic acid connects to diseases such as cancer and Alzheimer's disease. Its ability to disrupt protein phosphatase activity can promote tumorigenesis by causing uncontrolled cell growth and division particularly involving proteins like p53 and myc. In Alzheimer's disease the imbalance in phosphorylation induced by okadaic acid mimics tauopathy because of altered tau protein phosphorylation states. This makes okadaic acid a valuable research agent for understanding both cancer progression and neurodegenerative processes.