Abcam, ab84497, Anti-MCAF1 antibody

Size: 100µL
Rabbit Polyclonal MCAF1 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ATF7IP aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATF7IP aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q6VMQ6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MCAF1 also known as MBD1-containing chromatin-associated factor 1 functions as a transcriptional co-regulator interacting with various other proteins. With a molecular mass of approximately 89 kDa MCAF1 connects with methyl-CpG binding domains to regulate gene expression. The protein is highly expressed in tissues like the brain liver and spleen indicating its broad participation in important cellular processes.
Biological function summary
MCAF1 acts as a bridge between components of the chromatin and transcription machinery. It forms complexes with other proteins such as MBD1 and SETDB1 to influence gene silencing. These interactions allow MCAF1 to participate in the regulation of gene activation and repression via chromatin remodeling. Its role in modifying chromatin structure underlines its importance in controlling essential cellular functions like differentiation and proliferation.
Pathways
MCAF1 integrates into gene expression regulatory pathways and chromatin organization. It closely interacts with proteins such as SETDB1 and MBD1 to mediate the silencing pathway. The protein modulates pathway activities by changing the chromatin state impacting the expression of genes involved in cellular growth and division. These interactions make MCAF1 a significant player in transcriptional regulation through chromatin modifications.
Scientists have linked MCAF1 to neurological disorders and cancers. Aberrant expression or mutations in MCAF1 or its partner proteins like SETDB1 can contribute to cancer progression and metastasis by altering gene expression. In neurological contexts MCAF1 may play roles in disorders where chromatin remodeling impacts neuronal function. Understanding its interactions provides insights into disease mechanisms and highlights potential targets for therapeutic intervention.