Abcam, ab8469, Anti-Proteus spp antibody [31-17]

Size: 1mL
Mouse Monoclonal Proteus spp antibody. Suitable for ICC/IF and reacts with Proteus samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:31-17,
Isotype:IgG2a,
Light chain type:unknown,
Carrier free:No,
Reacts with:Proteus,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody reacts with approximately 50% of the Proteus spp. isolates tested

Product details:
This antibody reacts with bacteria in suspension and is therefore useful for detection of
Proteus spp
. in bacterial suspensions. Various systems can be used with this antibody to detect the presence of
Proteus spp.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-This product is sterile filtered., Storage buffer-pH: 7.3Preservative: 0.1% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Proteus spp. is a gram-negative bacterium that possesses versatile mechanical capabilities. Known for its flagellar motility Proteus spp. thrive in various environments typically in soil water and the intestinal tracts of humans and animals. This bacterium exhibits a unique swarming ability which is a coordinated movement that differentiates it from other bacteria. At a mechanical level its distinct ability to form crystalline-like biofilms on surfaces contributes to its persistence and survival. While the mass of individual components varies key structures like the flagella are essential for its motility and surface adherence.
Biological function summary
Proteus spp. participate in several functions critical for survival and adaptability. As an opportunistic pathogen it can cause infections when the host's defense is compromised. Its role in urea hydrolysis by producing urease is significant; this enzyme catalyzes the conversion of urea into ammonia and carbon dioxide increasing local pH. Proteus spp. do not form a complex with other proteins but their urease production impacts their environment.
Pathways
Proteus spp. influence nitrogen metabolism and biofilm formation pathways. Nitrogen metabolism plays a part in nutrient cycling particularly when Proteus breaks down urea. In biofilm formation it interacts with other proteins like quorum-sensing molecules that regulate gene expression related to community behavior. These processes are important for the adaptation of Proteus in various habitats.
Proteus spp. often associate with urinary tract infections and kidney stone development. The association with urinary tract infections arises from their motile nature enabling colonization of the urinary system. Urease the enzyme produced by Proteus plays a role in kidney stone formation by increasing ammonia levels which elevates pH and leads to crystal formation. These conditions highlight the importance of Proteus spp. in clinical settings underlining the need for efficient medical interventions to manage infections and complications.