Abcam, ab84816, Anti-HCN1 antibody [S70]

Size: 100µg
Mouse Monoclonal HCN1 antibody. Suitable for Flow Cyt, WB, IHC-P, IHC-Fr and reacts with Human, Rat, Mouse samples. Cited in 21 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat Hcn1 aa 750 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:S70,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, Flow Cyt, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat Hcn1 aa 750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9JKB0,
Specificity:No cross reactivity against HCN2

Product details:
The clone number has been updated from S70-28 to N70/28, both clone numbers name the same antibody clone.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HCN1 protein also known as hyperpolarization-activated cyclic nucleotide-gated channel 1 or HCN1 receptor is an important component in cellular electrical activity. It has a molecular mass of approximately 91 kDa. HCN1 channels are highly expressed in the heart and nervous system particularly in regions like the cortex and hippocampus. Their principal role is serving as pacemaker channels that regulate rhythmic activity in both neurons and cardiac cells.
Biological function summary
HCN1 channels contribute to the generation and modulation of electrical impulses. They belong to a family of ion channels activated by membrane hyperpolarization and modulated by cyclic nucleotides. These channels are part of a larger molecular complex that includes other HCN family members such as HCN2 and HCN4 which together generate coordinated ionic currents essential for maintaining the rhythmic activity.
Pathways
HCN1 channels significantly affect the pacing of cardiac and neuronal circuits. Within the cardiac tissue they partake in regulating heart rate through the If current or pacemaker current together with related proteins like HCN4. In the central nervous system their role extends to neuronal excitability and synaptic transmission interacting with signaling pathways that involve other ion channels and second messengers contributing to complex neuronal network activities.
Alterations in HCN1 function or expression levels can lead to various conditions. In the heart dysregulation of HCN1 is associated with arrhythmias potentially involving interactions with proteins like the HCN4 channel. In the nervous system abnormal HCN1 activity has been linked to epilepsy with potential involvement of other ion channel dysfunctions. Understanding these associations provides insight into treatment strategies targeting these specific ion channel pathways.