Abcam, ab84852, Anti-PDCD11 antibody [158C1a]

Size: 50µg
Mouse Monoclonal PDCD11 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDCD11 aa 1250-1450.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:158C1a,
Isotype:IgG2a,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PDCD11 aa 1250-1450. The exact immunogen used to generate this antibody is proprietary information.Q14690

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab84852 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Filtered through a 0.22 µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDCD11 also known as ALG-4 or HCCA2 is a nuclear protein weighing approximately 68 kDa. It is encoded by the PDCD11 gene located on chromosome 10. Researchers have observed its expression in multiple tissues with higher levels seen in lymphoid tissues and several cell lines. PDCD11 functions as a ribonucleoprotein suggesting a potential role in ribosome biogenesis and RNA processing.
Biological function summary
PDCD11 plays a role in the processing of small nucleolar RNAs (snoRNAs) and interacts as a component of ribosome biogenesis complexes. Studies indicate that it contributes to the maturation of the 18S rRNA essential for the assembly of the small ribosomal subunit. As part of the nucleolus PDCD11 assists in organizing the structure aiding the complex formation needed for efficient cellular function.
Pathways
PDCD11 integrates into genetic pathways linked with RNA processing such as transcription regulation and ribosome biogenesis frameworks. It connects with proteins like UTP6 and NOL11 within these pathways forming part of the complex machinery that coordinates the synthesis and processing of ribosomal RNA. These interactions ensure proper ribosomal assembly necessary for protein synthesis.
Researchers have linked PDCD11 to cancers such as leukemia and lymphoma. Alterations in its expression or function may disturb ribosome biogenesis influencing tumorigenesis. PDCD11's interactions with the MYC protein further highlight its potential role in oncogenic pathways where dysregulation could lead to uncontrolled cell proliferation. Understanding its involvement opens pathways for targeting ribosome biogenesis in cancer therapy.