Abcam, ab84873, Anti-STK38L/Ndr2 antibody [3563C2a]

Size: 100µg
Mouse Monoclonal STK38L/Ndr2 antibody. Suitable for WB and reacts with Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STK38L.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3563C2a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STK38L. The exact immunogen used to generate this antibody is proprietary information.Q9Y2H1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum.Filtered through a 0.22 µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK38L also known as Ndr2 is a member of the serine/threonine kinase family and shares similarities with other Ndr family members. This protein plays a significant mechanical role in several cellular processes including regulation of cell growth and cell division. STK38L has a molecular mass of approximately 54 kDa. Researchers have observed its expression in various human tissues such as liver kidney and heart indicating its widespread functional roles in the body.
Biological function summary
STK38L acts as an important regulator by coordinating cell cycle-related activities and influences apoptosis. It is known to participate as part of the larger signaling complex interacting with scaffold proteins to ensure proper cell function. The protein mediates these biological processes through phosphorylation impacting various signaling networks and helping cells respond to different physiological conditions effectively.
Pathways
STK38L integrates into key signaling pathways such as the Hippo pathway which is essential for controlling organ size through the regulation of cell proliferation and apoptosis. This pathway involves other proteins like MST1/2 and LATS1/2 which closely interact with STK38L to maintain cellular homeostasis. The interaction with these proteins illustrates STK38L's critical positioning in cellular communication networks affecting the pathway’s outcome on cellular behavior.
STK38L is associated with certain cancers and neurodegenerative disorders. Aberrant function or regulation of STK38L may contribute to the development of conditions such as hepatocellular carcinoma and Alzheimer's disease. BRCA1 and Tau proteins are related to these diseases where STK38L’s interaction with or regulation of these proteins can influence disease progression providing potential therapeutic targets for intervention.