Abcam, ab85090, Anti-BZW1/Protein Orf antibody

Size: 100µg
Rabbit Polyclonal BZW1/Protein Orf antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human BZW1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BZW1. The exact immunogen used to generate this antibody is proprietary information.Q7L1Q6

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BZW1 also known as Protein Orf is a member of the basic leucine zipper (bZIP) family of proteins. The mass of BZW1 is approximately 42 kDa. It is mainly expressed in the nucleus of cells. BZW1 plays a role in the regulation of transcription and translation processes. This regulation occurs through its interaction with specific sequences on the DNA and RNA contributing to the modification of gene expression.
Biological function summary
BZW1 influences cell growth and proliferation by engaging in the regulation of gene transcription. It can interact with other proteins to form complexes that modulate these processes. BZW1 adjusts protein synthesis rates by acting at the level of translational control affecting cellular responses to different growth conditions. Its function supports overall cellular homeostasis by ensuring proteins are produced as needed.
Pathways
BZW1 is integral to both the mTOR and eIF2 signaling pathways which are critical in regulating protein synthesis and stress responses. It is related to other proteins like mTOR and eIF2α within these pathways and its activity can influence how cells respond to nutrient availability and environmental changes.
Alterations in BZW1 expression have associations with cancer and neurodegenerative diseases. In cancer dysregulation of BZW1 can affect the cell cycle by impacting the proteins involved like p53 thereby promoting uncontrolled cell proliferation. In neurodegenerative diseases changes in its function can disrupt protein homeostasis leading to the accumulation of proteins that contribute to disease progression and pathways involving proteins like α-synuclein.