Abcam, ab85346, Anti-DLL1 antibody

Size: 100µg
Goat Polyclonal DLL1 antibody. Suitable for WB, ICC/IF and reacts with Rat, Mouse, Human samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human DLL1 aa 100-200.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human, Mouse,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DLL1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.O00548

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab85346 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as Delta-like 1 (DLL1) also referred to as DLL 1 or DLL1 protein is an essential component in various cellular mechanisms. DLL1 typically has a molecular mass of approximately 80 kDa. This protein is mainly expressed in tissues related to development such as the nervous system bone marrow and certain parts of the embryonic organs. DLL1 functions mechanic-wise as a ligand for the Notch receptor family playing a role in signal transduction and influencing cell fate decisions.
Biological function summary
Delta-like 1 protein is involved in several cell differentiation processes impacting tissue development. The protein is a member of the Notch signaling pathway which is important for mediating communication between adjacent cells. It interacts with Notch receptors to regulate transcriptional activities and promote different cell lineages. DLL1 does not function in isolation; it works as a part of a larger protein complex that includes intracellular domains and other signal modifiers.
Pathways
Delta-like 1 fits into the Notch signaling pathway and the Wnt pathway. In the Notch signaling pathway DLL1 engages with Notch receptors to drive transcriptional responses important for embryogenesis and cell fate choices. In the Wnt pathway DLL1 interacts to modulate cellular growth and differentiation often in conjunction with proteins such as Jagged1 and Notch1. These pathways are essential in maintaining stem cell niches and influencing neurogenesis.
Delta-like 1 protein bears significance in oncological and congenital disorders. Dysregulation of DLL1 is associated with cancers like T-cell acute lymphoblastic leukemia where altered Notch signaling plays a role in tumor progression. Additionally abnormalities in DLL1 expression relate to congenital heart defects indicating its role in cardiac development. DLL1's interaction with Notch receptors such as Notch3 appears significant in these contexts making it a potential target for therapeutic intervention in both cancer and congenital disorder management.