Abcam, ab85824, Anti-MATH2/NEUROD6 antibody

Size: 100µg
Rabbit Polyclonal MATH2/NEUROD6 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Replenishment batches of ab85824 are tested in WB. Previous batches were additionally validated in ICC/IF. This application is still expected to work and is covered by our Abpromise guarantee.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein MATH2 also known as NEUROD6 is important for the development and differentiation of neurons. It acts as a transcription factor regulating gene expression. With a molecular weight of approximately 39 kDa MATH2/NEUROD6 is expressed in the central nervous system particularly in the brain. This protein belongs to the basic helix-loop-helix (bHLH) family which are known for binding to specific DNA sequences to modulate transcription.
Biological function summary
MATH2/NEUROD6 plays a critical role in the nervous system. It influences neuronal survival outgrowth and synaptogenesis. Although not part of a larger protein complex it functions closely with other bHLH proteins to promote neurogenesis. Its similarity to NEUROD1 suggests overlap in their biological roles especially in the regulation of development in the nervous system.
Pathways
MATH2/NEUROD6 is key in the neurogenesis pathway facilitating the formation and specialization of neurons. It works alongside proteins such as MAPK which regulate various cellular activities including proliferation differentiation and response to extracellular stimuli. MATH2/NEUROD6 also interacts within the signaling pathways that affect neuronal differentiation aligning with other bHLH proteins for synaptic plasticity.
MATH2/NEUROD6 associates with neurodevelopmental disorders. Abnormal expression levels are linked to diseases such as Alzheimer's and Parkinson's due to their role in neuronal survival and plasticity. The protein's connection with NEUROD1 and its involvement in maintaining proper brain function underline its importance in research on neurological diseases.