Abcam, ab85832, Anti-HERC2 antibody

Size: 100µg
Rabbit Polyclonal HERC2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human E3 ubiquitin-protein ligase HERC2 aa 4750 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human E3 ubiquitin-protein ligase HERC2 aa 4750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95714

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HERC2 also known as E3 ubiquitin-protein ligase HERC2 acts mechanically as an enzyme involved in the ubiquitination process. It has a mass of approximately 527 kDa. HERC2 localizes in the nucleus and cytoplasm with a wide expression in many tissues including the brain and liver. It functions as an important regulator in protein homeostasis by tagging specific proteins for degradation via the proteasome.
Biological function summary
HERC2 plays a role in various cellular processes including DNA repair and cell cycle regulation. It forms complexes with other proteins such as USP7 and regulates p53 stability impacting processes like apoptosis and cell proliferation. Additionally HERC2 is important in maintaining genomic integrity by participating in DNA damage response pathways.
Pathways
Scientists observe HERC2 involvement in the DNA damage repair pathway and ubiquitin-proteasome system. HERC2 interacts with proteins such as BRCA1 which is important for homologous recombination repair and E3 ubiquitin ligases which coordinate protein degradation. Its function ensures proper regulation of cellular processes by controlling the turnover of key regulatory proteins.
Mutations or dysregulation of HERC2 associate with cancer and neurodevelopmental disorders. In cancer HERC2's interaction with p53 highlights its role in tumor suppression; aberrations in this pathway can lead to tumor development. In neurodevelopmental disorders its connection with the ATRX protein suggests implications in disorders such as autism spectrum disorders due to its role in chromatin remodeling and gene expression regulation.