Abcam, ab85999, Anti-FOXK1/MNF antibody

Size: 100µL
Rabbit Polyclonal FOXK1/MNF antibody. Suitable for IHC-P, IP, WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FOXK1 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FOXK1 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P85037

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab85999 was affinity purified using an epitope specific to FOXK1 / MNF immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FOXK1/MNF protein often called Forkhead Box K1 is a transcription factor that regulates gene expression linked to cell proliferation and differentiation. It has the molecular weight of approximately 84 kDa. Expressed in various tissues including muscle and brain FOXK1/MNF plays an essential role in regulating specific gene targets. The protein interacts with DNA via its forkhead domain influencing the transcriptional activity of numerous genes important for cellular functions.
Biological function summary
FOXK1/MNF is involved in the regulation of cell cycle progression and muscle regeneration. It forms part of a transcriptional complex that modulates gene expression to control these processes. In muscle tissue FOXK1/MNF influences the activation of satellite cells which are necessary for muscle repair and growth. This protein’s function in regulating cellular proliferation highlights its significance in tissue development and regeneration.
Pathways
The FOXK1/MNF protein is instrumental in the Wnt signaling and PI3K/AKT pathways. These pathways are significant for controlling cell proliferation differentiation and survival. Within these pathways FOXK1/MNF interacts with proteins such as beta-catenin in the Wnt signaling pathway. Through these interactions it modulates the transcription of genes responsible for various cellular functions further underlining its role in tissue regeneration and cancer development.
FOXK1/MNF links notably with certain cancers and muscular dystrophies. In cancer its overexpression can lead to unchecked cell proliferation and tumor growth interacting closely with proteins like PTEN a known tumor suppressor. In muscular dystrophy FOXK1/MNF may influence the disease progression by affecting the muscle regeneration process a vital element in maintaining muscle integrity. Understanding its expression and regulation can provide insights into the mechanisms driving these diseases and offer targets for potential therapeutic interventions.