Abcam, ab86001, Anti-CAMSAP1 antibody

Size: 100µL
Rabbit Polyclonal CAMSAP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CAMSAP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CAMSAP1. The exact immunogen used to generate this antibody is proprietary information.Q5T5Y3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAMSAP1 also known as Calmodulin Regulated Spectrin Associated Protein 1 functions in the stabilization of non-centrosomal microtubules by binding to their minus ends. It has a molecular weight of approximately 170 kDa. Researchers have found its expression in various tissues with significant levels in the brain and epithelial cells. This protein plays an important role in maintaining cellular architecture by regulating the organization and stability of the microtubule network.
Biological function summary
By maintaining microtubule integrity CAMSAP1 supports processes like cell division intracellular transport and cellular polarity. It does not act alone but interacts as part of larger complexes that include other microtubule-associated proteins. These interactions allow it to influence centrosome-independent microtubule arrays and contribute to the anchoring of microtubule minus ends.
Pathways
CAMSAP1 integrates into the cytoskeleton organization and cell division pathways. In these pathways it collaborates with key proteins like microtubule-associated proteins MAP7 and CLASP1 aiding the proper segregation of chromosomes during mitosis. The regulation of microtubules by CAMSAP1 and its associations with related proteins effectuates these critical cellular processes.
CAMSAP1 has links to neurodevelopmental disorders and cancer. Dysfunction in its activity can lead to improper neuronal positioning contributing to developmental brain disorders. In cancer alterations in CAMSAP1 expression impact cell migration and tumor growth. It functions alongside proteins like MAP7 and spectrin which also participate in these disease processes highlighting its influence in pathological states affecting both neuronal and cancer cell proliferation.