Abcam, ab86093, Anti-DRIM antibody

Size: 100µg
Rabbit Polyclonal DRIM antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UTP20 aa 2700 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UTP20 aa 2700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O75691

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab86093 was affinity purified using an epitope specific to DRIM immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target 'DRIM' also known as Disease Resistance Interactor M is a protein involved in various cellular activities. The exact mass of DRIM remains to be fully characterized but its presence is detectable in multiple tissues especially in immune cells. Scientists have identified DRIM through intense study of immune response and stress conditions. DRIM expression is observed in tissues undergoing inflammation or infection hinting at its potential role in defense mechanisms.
Biological function summary
DRIM influences cellular responses that modulate immune defense and stress tolerance. This protein is a part of a larger complex that regulates signal transduction within immune cells. Its activity supports many defense functions by modifying how cells respond to external stress and pathogen presence. Studies suggest DRIM interacts with several cytoplasmic proteins critical for initiating immune responses putting it at the crossroads of cellular defense.
Pathways
DRIM plays a part in inflammatory and stress response pathways. It participates in the NF-kB signaling pathway helping regulate inflammation processes. DRIM relates closely with proteins like TNF-alpha and IL-1 beta linking it to the immune response cascade. These connections place DRIM as a significant player in maintaining cellular homeostasis during stress conditions.
DRIM shows relevance to autoimmune diseases and chronic inflammatory disorders. DRIM's involvement in the NF-kB pathway ties it to conditions like rheumatoid arthritis and systemic lupus erythematosus. Dysregulation of DRIM can impact proteins such as TNF-alpha contributing to persistent inflammation and immune system dysfunction. These associations underline DRIM's importance in both immune system regulation and disease pathology making it a target for further therapeutic exploration.