Abcam, ab86307, Anti-TOR1AIP1 antibody

Size: 100µL
Rabbit Polyclonal TOR1AIP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TOR1AIP1 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TOR1AIP1 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q5JTV8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab86307 was affinity purified using an epitope specific to TOR1AIP1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TOR1AIP1 also known as lamina-associated polypeptide 1 (LAP1) is a mechanical protein involved in nuclear envelope structural integrity. This protein has an approximate mass of 75 kDa and is mainly found in the inner nuclear membrane. It interacts closely with components of the nuclear lamina particularly lamin A/C to contribute to the nuclear envelope architecture and maintain cellular functions.
Biological function summary
The protein known as LAP1 plays a role in modulating nuclear-cytoplasmic transport and chromatin dynamics. It is associated with the inner nuclear membrane complex and works in tandem with other nuclear lamins. This interaction is essential for processes like gene expression regulation and nuclear structure maintenance facilitating cellular response to mechanical stress.
Pathways
TOR1AIP1 participates in pathways involving nuclear envelope assembly and disassembly during cell division. It is integrated within the mitotic nuclear envelope reassembly pathway and interacts with proteins like emerin and torsinA. These proteins are essential for regulated nuclear envelope dynamics as well as maintaining proper chromatin organization during mitotic events.
Mutations in TOR1AIP1 have been linked to congenital muscular dystrophies and torsion dystonia. These conditions often arise from disrupted nuclear envelope integrity and abnormal cellular responses to mechanical stress. The close interaction with proteins such as emerin and torsinA underlines the connection between nuclear envelope dysfunction and the pathogenesis of these muscular and movement disorders.