Abcam, ab87801, Anti-NSP 5 alpha 3 alpha antibody

Size: 100µL
Rabbit Polyclonal NSP 5 alpha 3 alpha antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SPECC1 aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SPECC1 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.Q5M775

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab87801 was affinity purified using an epitope specific to NSP 5 alpha 3 alpha immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NSP5 alpha 3 alpha protein also known as non-structural protein 5 is an important player in viral replication. This protein weighs approximately 32 kilodaltons and is expressed primarily in cells infected by certain types of viruses including coronaviruses. NSP5 alpha 3 alpha functions as a protease which is an enzyme that cleaves other proteins to facilitate the viral replication process. It is often considered the main protease of the virus essential for processing the viral polyprotein into functional units necessary for the virus lifecycle.
Biological function summary
The NSP5 alpha 3 alpha protein acts as a pivotal component of the viral replication machinery. It is a critical member of the viral replication complex which consists of non-structural proteins that work together to produce viral RNA. These complexes form in the cytoplasm of infected host cells and coordinate the replication and transcription of the viral genome. The activity of NSP5 alpha 3 alpha protease cleaves the viral polyprotein at specific sites releasing other non-structural proteins that perform various roles in replication.
Pathways
NSP5 alpha 3 alpha protein plays a central role in the viral RNA synthesis pathway. Its proteolytic activity is essential for the maturation of several non-structural proteins that participate in RNA replication and transcription. NSP5 alpha 3 alpha functions closely with NSP12 an important polymerase enzyme within the viral RNA-dependent RNA polymerase complex. Together these proteins ensure continuous and efficient viral RNA synthesis which is important for successful viral propagation within the host.
NSP5 alpha 3 alpha protein is intimately linked to respiratory diseases such as COVID-19. The protein's role in viral replication makes it a significant target for developing antiviral therapies aimed at inhibiting its protease activity. The NSP5 alpha 3 alpha protein also connects to other viral proteins such as NSP3 and NSP16 which are implicated in immune evasion mechanisms that allow the virus to persist and cause severe disease symptoms. Understanding the interactions of NSP5 alpha 3 alpha with these proteins may provide new insights into therapeutic approaches for combatting these infections.