Abcam, ab88514, Anti-RPL29 antibody

Size: 50µg
Mouse Polyclonal RPL29 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RPL29.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RPL29.P47914

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL29 also known as ribosomal protein L29 is a structural component of the large 60S ribosomal subunit. It has a molecular mass of approximately 17 kDa. This protein contributes to ribosome function by connecting with rRNA and other ribosomal proteins to aid protein synthesis. RPL29 shows strong expression in tissues with high protein turnover such as the liver and pancreas where efficient protein production is necessary for maintaining cellular functions.
Biological function summary
RPL29 takes part in the assembly of the ribosome which is essential for the translation process in protein synthesis. It is not found alone; instead it becomes integrated into the large ribosomal subunit. This integration is critical for the assembly and stability of the ribosomal structure. Without proper RPL29 incorporation ribosome function and consequently cellular protein synthesis can become impaired.
Pathways
The ribosomal protein RPL29 plays important roles in both the translation and ribosome biogenesis pathways. It functions alongside other ribosomal proteins like RPL5 and RPL11 in these pathways to ensure correct assembly and functionality of ribosomes. Ribosome biogenesis is a highly-regulated process that starts in the nucleolus and extends into the cytoplasm involving steps important for cell growth and division.
Mutations or dysregulation in RPL29 have been linked with certain types of cancers such as colorectal carcinoma. Cancerous cells often exhibit altered ribosomal function to support their increased need for protein synthesis. RPL29’s interaction with other ribosomal proteins like RPL11 affects ribosomal stress responses which can impact cancer progression. Additionally aberrations in ribosome function where RPL29 is a player are associated with ribosomopathies a group of disorders characterized by defective ribosome biogenesis and function.