Abcam, ab88563, Anti-Synapsin III antibody

Size: 50µg
Mouse Polyclonal Synapsin III antibody. Carrier free. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Synapsin-3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Synapsin-3.O14994

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synapsin III also known as SYNIII is a phosphoprotein with an approximate mass of 64 kDa. Like other synapsins Synapsin III is mostly found in the brain where it plays an important role in synaptic function. It shows a widespread expression with notable abundance in the hippocampus and cerebral cortex. The protein associates with synaptic vesicles and neuronal membranes assisting in neurotransmitter release during neuronal communication.
Biological function summary
Synapsin III serves an important function in the regulation of neurotransmitter release and synaptic plasticity. It binds to synaptic vesicles and cytoskeletal elements organizing vesicle trafficking at the presynaptic terminal. Synapsin III is not part of a known larger protein complex but often works in concert with other synaptic proteins to influence synaptic vesicle dynamics. Its regulation of vesicle mobilization and docking highlights its function in fine-tuning neuronal communication.
Pathways
Synapsin III operates in nerve terminal signaling especially in pathways involving synaptic vesicle cycle. It contributes to processes in the synaptic vesicle cycle details of which comprise vesicle trafficking and neurotransmitter release. In these pathways it interacts with proteins such as Synapsin I and Synapsin II which share responsibilities in neurotransmitter regulation. These proteins together maintain synaptic activity under various physiological conditions.
Synapsin III has connections with neurological conditions such as schizophrenia and attention deficit hyperactivity disorder (ADHD). Studies indicate alterations in Synapsin III expression levels or function may contribute to synaptic impairments observed in these disorders. Additionally there is interaction with proteins like DISC1 (Disrupted in Schizophrenia 1) which further links Synapsin III to schizophrenia. Synapsin III sits in the broader context of synaptic proteins critical for normal cognitive functions.