Abcam, ab88746, Anti-GABPB2/Nuclear respiratory factor 2 antibody

Size: 50µg
Mouse Polyclonal Nuclear respiratory factor 2 antibody. Carrier free. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GABPB1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GABPB1.Q06547

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nuclear respiratory factor 2 (NRF2) also known as GABP (GA-binding protein) is a transcription factor that regulates the expression of genes involved in cellular energy metabolism and mitochondrial biogenesis. NRF2 is composed of several subunits with GABPA as its DNA-binding subunit having a molecular mass approximately of 50 kDa. This protein is expressed in various tissues with higher concentrations found in metabolic active tissues such as the brain and muscle. It plays a significant role in controlling the transcription of genes tied to mitochondrial function and overall cellular energy homeostasis.
Biological function summary
NRF2 interacts with other protein factors to initiate and regulate transcription. It functions as part of the GA-binding protein complex interacting with other transcription factors to control gene expression. This regulatory mechanism is vital for cellular adaptation to changing energy demands and influences oxidative stress responses. NRF2 is actively involved in the induction of antioxidant enzymes and proteins that protect the cell from oxidative damage contributing to cellular longevity and function.
Pathways
NRF2 plays an important role in the oxidative stress response pathway and mitochondrial biogenesis. It interacts with other proteins like KEAP1 which regulates NRF2 stability and activity. In the oxidative stress response NRF2 translocates to the nucleus to activate genes associated with antioxidant responses whereas in mitochondrial biogenesis it influences the expression of genes involved in mitochondrial replication and energy production. These pathways are critical for maintaining cellular health and energy supply in response to metabolic demands.
NRF2 has links to neurodegenerative conditions and certain cancer types. In neurodegenerative diseases such as Alzheimer's impaired NRF2 function can lead to increased oxidative stress and neuronal damage. Altered NRF2 signaling is also implicated in some cancers where its role in regulating cell growth and survival becomes dysregulated. NRF2's interaction with KEAP1 is significant in both areas; mutations or changes in KEAP1 can affect NRF2 levels and activity contributing to disease progression and resistance to therapies.