Abcam, ab89075, Anti-DDX42 antibody

Size: 50µg
Mouse Polyclonal DDX42 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DDX42.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human DDX42.Q86XP3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DDX42 protein also known as DEAD-box protein 42 is a member of the DEAD-box protein family characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). DDX42 has a molecular mass of approximately 102 kDa. This protein functions as an ATP-dependent RNA helicase which means it unwinds RNA structures using energy from ATP hydrolysis. It is expressed in various tissues but shows a higher expression level in proliferating cells pointing to its role in cellular growth and division processes.
Biological function summary
The DDX42 protein participates in RNA metabolic processes which include RNA splicing export degradation and ribosome assembly. This helicase plays a role in the regulation of gene expression by remodeling RNA secondary structures facilitating its function in various RNA processing phases. DDX42 is sometimes found as part of larger protein complexes that perform RNA structural modifications necessary for proper cellular function.
Pathways
DDX42 interacts with key biological pathways involved in RNA processing and cellular stress responses. It plays a part in the spliceosome an important component of the splicing machinery which is responsible for the removal of introns from pre-mRNA. DDX42 has functional interactions with other DEAD-box proteins such as DDX5 and DDX17 within these pathways working together to ensure correct RNA processing and expression.
DDX42 has been linked to certain forms of cancer including leukemia where RNA processing dysregulation is common. This connection may involve interactions with oncogenic proteins like c-Myc which influences transcription and RNA processing. Additionally researchers have observed potential roles for DDX42 in neurological disorders due to its involvement in RNA metabolism and cellular stress response pathways implicating proteins such as TDP-43 a protein associated with amyotrophic lateral sclerosis (ALS).