Abcam, ab89324, Anti-CXCL1/2/3 (pan GRO) antibody [MM0214-11B27]

Size: 100µg
Mouse Monoclonal CXCL1/GRO alpha antibody. Carrier free. Suitable for WB, FuncS (Neut/Block) and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL3.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:MM0214-11B27,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Human,
Applications:FuncS (Neut/Block), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CXCL3.P19876

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-The IgG fraction of culture supernatant was purified by Protein G affinity chromatography., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXCL1 also known as GRO alpha CXCL2 and GRO gamma refers to chemokines that are important in immune response. These chemokines are small proteins with a mass of about 8 kDa. They signal through the activation of the chemokine receptor CXCR2. CXCL1/GRO alpha CXCL2 and GRO gamma express in various tissues including epithelial cells and immune cells like neutrophils. They function by recruiting these immune cells to sites of inflammation or injury.
Biological function summary
CXCL1/GRO alpha CXCL2 and GRO gamma are involved in the recruitment and activation of neutrophils. Neutrophils are the first responders in the immune response. These chemokines play a role in angiogenesis and wound healing by stimulating the migration and proliferation of endothelial cells. They do not function as part of a larger protein complex but operate independently in signaling pathways. Their chemotactic activities are essential for proper immune surveillance and response to infections.
Pathways
These chemokines are integral to the NF-kB signaling pathway and MAPK pathway. Through these pathways they mediate inflammatory responses and cellular proliferation. CXCL1/GRO alpha and its family members interact with proteins such as CXCR2 and MAPK which help relay signals for gene expression related to inflammation and cell survival. Their interaction with these pathways highlights their role in initiating and modulating inflammatory processes.
CXCL1/GRO alpha CXCL2 and GRO gamma have associations with inflammatory diseases like rheumatoid arthritis and cancer especially melanoma. In rheumatoid arthritis these chemokines contribute to the recruitment of neutrophils and other immune cells to the joints leading to chronic inflammation. In cancer particularly melanoma they can promote tumor growth by enhancing angiogenesis and suppressing immune response due to the involvement of CXCR2 signaling. Understanding these chemokines involves examining proteins like CXCR2 which play a direct role in disease progression through these inflammatory and cancer pathways.