Abcam, ab89568, Anti-LTB antibody [MM0462-3J26]

Size: 50µg
Mouse Monoclonal LTB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LTB.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:MM0462-3J26,
Isotype:IgG2,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human LTB.Q06643,
Specificity:ab89568 detects Lymphotoxin Beta.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LTB also known as Lymphotoxin Beta is a member of the TNF (tumor necrosis factor) superfamily. Its molecular weight is approximately 33 kDa. LTB is expressed mainly in lymphoid tissues particularly in the spleen and thymus. This protein exists as a membrane-bound homotrimer or heterotrimer with Lymphotoxin Alpha influencing cellular processes both as individual units and in complex structures.
Biological function summary
LTB contributes to the formation and maintenance of secondary lymphoid tissues. LTB forms a complex with Lymphotoxin Alpha in a heterotrimeric arrangement which links it to immune responses by managing lymphoid organogenesis. It participates in regulating inflammation and maintaining organized lymphoid architecture impacting germinal center formation in response to antigenic stimulation.
Pathways
LTB plays a significant role in the NF-kB signaling pathway and lymphoid tissue organization. It interacts with the NF-kB pathway by engaging lymphotoxin-beta receptor (LTBR) leading to the activation of transcription factors. This interaction is vital in ensuring the proper migration and positioning of leukocytes associating LTB closely with proteins like LTBR and Rel proteins.
LTB demonstrates a significant link to autoimmune diseases and lymphomas. Its overexpression can contribute to chronic inflammatory conditions and certain types of B-cell lymphomas often through dysregulation of the NF-kB signaling pathway. In these conditions LTB interacts closely with associated molecules like LTBR and potentially with other TNF family members indicating its influence in pathological inflammatory pathways.