Abcam, ab8991, Anti-Integrin beta 1d antibody [2B1]

Size: 100µg
Mouse Monoclonal Integrin beta 1 antibody. Suitable for WB, IHC and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human ITGB1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2B1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ITGB1. The exact immunogen used to generate this antibody is proprietary information.P05556,
Epitope:Cytoplasmic domain, C-terminal. Isoform of the Integrin b1 subunit present in cardiac and skeletal muscle.,
Specificity:Recognizes specifically the cytoplasmic domain of integrin subunit beta 1D present in cardiac and skeletal muscle.A broad species reactivity is expected because of the conserved nature of the epitope.

Product details:
The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin beta 1d also known as ITGB1D is a protein mechanically involved in cell adhesion and signal transduction processes. It is a splice variant of the integrin beta-1 subunit which forms heterodimers with various alpha subunits. Integrin beta 1d has a mass of approximately 88 kDa and is expressed predominantly in cardiac and skeletal muscle tissues. This expression pattern supports its specialized functions in muscle cell physiology.
Biological function summary
Integrin beta 1d plays a critical role in muscle function. It remains part of the integrin family which mediates interactions between the extracellular matrix and the cytoskeleton. Integrin beta 1d associates with other proteins to form complexes that influence cell signaling growth and survival. In muscular tissues this integrin variant facilitates communication between the cells and their external environment supporting structural integrity and mechanical stability.
Pathways
Integrin beta 1d contributes significantly to the integrin signaling and focal adhesion pathways. In these pathways it interacts with proteins such as focal adhesion kinase (FAK) and talin modulating cell migration and differentiation. Through the beta-1 integrin pathways it influences a variety of cellular responses emphasizing its importance in cellular adhesion mechanics and signal transmission processes in muscle cells.
Integrin beta 1d is linked to specific muscular pathologies. Its abnormal expression or dysfunction associates with muscular dystrophies including Becker muscular dystrophy. In these conditions integrin beta 1d interacts with laminins and dystrophin proteins important for muscle fiber strength and integrity. This association highlights its role in maintaining muscle health and the serious consequences of its impaired function.