Abcam, ab90651, Anti-MLN51/CASC3 antibody

Size: 20µg / 100µL
Rabbit Polyclonal MLN51/CASC3 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CASC3 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CASC3 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O15234

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MLN51 also known as CASC3 is a protein that measures approximately 95 kDa. This protein plays an important role in RNA processing mechanisms including mRNA surveillance and transport by serving as a component of the exon junction complex (EJC). MLN51 is widely expressed throughout various tissues indicating its significant role in maintaining cellular function across different biological systems.
Biological function summary
MLN51/CASC3 participates actively in the formation and stability of the EJC a multiprotein complex essential for post-transcriptional regulation of mRNA. By associating with spliced mRNA the EJC marks the transcript for downstream processes such as localization translation and degradation. MLN51 lends stability to the complex making it an important player in ensuring correct mRNA processing and stability.
Pathways
MLN51/CASC3 integrates its biological functions into essential regulatory pathways like the nonsense-mediated mRNA decay (NMD) pathway. NMD is important for the recognition and decay of mRNAs containing premature termination codons. Within the NMD pathway MLN51 interacts with other EJC components such as eIF4AIII and MAGOH facilitating accurate surveillance of mRNA transcripts and ensuring fidelity in gene expression processes.
MLN51/CASC3 has significant implications in cancer and neurological disorders. Dysregulation of EJC components including MLN51 has been linked to the development and progression of certain cancers possibly due to aberrations in mRNA processing. Moreover neurological disorders have shown connections to malfunctions in the NMD pathway highlighting the role of MLN51 in maintaining neural integrity. In these contexts MLN51/CASC3 operates alongside proteins like UPF1 in safeguarding cellular homeostasis.