Abcam, ab91101, Anti-CD160 antibody [CNX46-3]

Size: 100µg
Rat Monoclonal CD160 antibody CNX46-3. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:CNX46-3,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Mouse Cd160.O88875

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD160 also known as BY55 is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 27 kDa. This protein is expressed on the surface of natural killer (NK) cells CD8+ T cells and certain NKT cells. It functions as a receptor for MHC class I molecules and HLA-C playing a role in regulating immune responses. Researchers have also identified its expression in some endothelial cells.
Biological function summary
The protein CD160 plays a role in immune modulation by interacting with major histocompatibility complex (MHC) class I ligands. It participates in the immune response by enhancing cytotoxic activity in NK and CD8+ T cells therefore influencing cell-mediated immunity. CD160 does not associate with large signal transduction complexes but operates as a standalone receptor capable of mediating cellular effects upon ligand binding. Although primarily known for its role in immune modulation CD160 can impact endothelial functions suggesting a broader biological significance.
Pathways
CD160 engages in the pathway associated with immune cell signaling. It operates within the natural killer cell signaling cascade contributing to the regulation of cell-mediated cytotoxicity. In the context of adaptive immunity CD160 influences the T cell receptor signaling pathway indirectly coordinating its actions with proteins such as NKG2D and PD-1. These interactions are important in how immune cells assess threats and modulate responses.
CD160 has implications in chronic inflammatory and autoimmune conditions. It is linked to disorders such as inflammatory bowel disease and psoriasis where immune regulation is disrupted. Its interaction with other proteins such as PD-1 may either exacerbate or alleviate symptoms depending on the pathological context. Understanding CD160's role provides insights into therapeutic strategies aimed at modulating immune responses in these conditions.