Abcam, ab91214, Anti-gp64 antibody [AcV5]

Size: 100µg
Mouse Monoclonal TLS/FUS antibody. Suitable for WB and reacts with Autographa californica nucleopolyhedrovirus samples. Cited in 5 publications. Immunogen corresponding to Cell preparation containing gp64 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:AcV5,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Autographa californica nucleopolyhedrovirus,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab91214 reacts with the gp64 envelope protein of the baculovirus Autographa californica (AcMNPV).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The gp64 also known as glycoprotein 64 is a viral envelope protein that mechanically facilitates the fusion and entry of viral particles into host cells. It has an approximate mass of 64 kDa. Gp64 is expressed on the surface of baculoviruses which are viruses commonly used in insect cell systems. It plays an important role in the infection process by mediating membrane fusion between the virus and the host cell ensuring the delivery of viral DNA into the host.
Biological function summary
Gp64 functions as a critical component in the lifecycle of baculoviruses. During the infection cycle it facilitates the binding and entry of viral particles acting as a fusion protein. Gp64 is a part of the larger viral envelope protein framework which helps the virus adapt and interact with the host cell's membrane. Its role extends beyond simple attachment as it initiates the processes leading to successful viral replication within the host cell.
Pathways
Gp64 participates in the endocytosis pathway important for viral entry into host cells. It interacts with cellular membrane proteins both directly and indirectly ensuring fusion and release of viral contents. Gp64 shares a functional relationship with other viral envelope proteins like those found in orthologous systems such as the vesicular stomatitis virus G protein. This interaction highlights its integral role in the viral infection process.
Gp64 is notably associated with vector systems used in therapies and vaccinations particularly in cancer treatments. While not directly linked to causing diseases its role in facilitating baculovirus entry has made it an important target in designing vectors for gene delivery. Gp64 interacts indirectly with proteins related to immune response and cell signaling during its use in therapeutic models providing potential pathways in treating disorders like cancer.