Abcam, ab91490, Anti-PA1 antibody

Size: 100µg
Rabbit Polyclonal PA1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PAGR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PAGR1. The exact immunogen used to generate this antibody is proprietary information.Q9BTK6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PA1 also known as Protein A1 is a protein involved in various cellular processes. It has a molecular mass of approximately 50 kDa. PA1 is often expressed in the cytoplasm and nucleus of cells showing widespread distribution across different tissues. The protein exhibits certain domains that enable it to interact with other proteins facilitating its role in cellular dynamics.
Biological function summary
PA1 acts as part of a multiprotein complex involved in regulating gene expression. It influences the transcriptional machinery by interacting with transcription factors and co-regulators. These interactions enable PA1 to modulate the expression of genes essential for cell cycle progression and cellular differentiation. Researchers have also observed PA1's participation in maintaining cellular homeostasis through its regulatory roles.
Pathways
PA1 notably participates in the MAPK and apoptosis pathways. Its involvement in the MAPK pathway impacts cellular responses to various stimuli leading to cell proliferation or differentiation. In the apoptosis pathway PA1 interacts with proteins such as BAX and BCL2 suggesting a role in controlling programmed cell death. These interactions highlight PA1's influence in balancing cell survival and death under normal and stress conditions.
PA1 has been implicated in cancer and neurodegenerative diseases. Altered expression or mutation of PA1 associates with tumor progression and poor prognosis in several cancers. In neurodegenerative disorders such as Alzheimer's disease PA1's interaction with proteins like tau and amyloid-beta contributes to pathological changes. Understanding PA1's role in these contexts can aid in developing targeted therapeutic strategies.