Abcam, ab91623, Anti-FRK antibody [4E1]

Size: 100µL
Mouse Monoclonal FRK antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRK.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4E1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FRK. The exact immunogen used to generate this antibody is proprietary information.P42685

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRK also known as FYN-related kinase or RAK is a non-receptor tyrosine kinase with a molecular mass of approximately 56 kDa. This protein is predominantly expressed in epithelial tissues including those of the breast kidney and liver. FRK displays substrate specificity and catalytic function by phosphorylating specific tyrosine residues on target proteins which influences cellular processes such as proliferation and differentiation.
Biological function summary
This kinase contributes to the regulation of cell cycle progression and apoptosis. FRK acts solo as well as part of larger signal transduction complexes. It plays a vital role in limiting uncontrolled cellular growth which is particularly significant in maintaining tissue homeostasis. FRK regulates various molecular interactions essential for cell adhesion and communication adding another layer of control over cell physiology.
Pathways
FRK integrates into signaling pathways like the PI3K/AKT and MAPK pathways. These pathways are critical for mediating responses to growth signals and stress conditions. FRK's activity modulates protein interactions with key molecules such as p53 and PTEN influencing downstream effects that control cell cycle checkpoints and apoptosis. By interacting with these pathways FRK helps to balance cell proliferation and survival in response to extracellular cues.
FRK has implications in cancer development particularly in breast cancer. Altered FRK expression or activity has been associated with tumor progression and resistance to treatment. FRK interacts with proteins such as BRCA1 contributing to its role in DNA damage response and tumor suppression. Additionally FRK's aberrant activity links to certain forms of renal disorders where it impacts cellular responses in renal tissue often through modulation of E-cadherin and β-catenin in epithelial cells.