Abcam, ab9191, Anti-Streptococcus pyogenes Group A Carbohydrate antibody

Size: 500µg
Goat Polyclonal Streptococcus pyogenes Group A Carbohydrate antibody. Carrier free. Suitable for IP, ELISA, Dot, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Streptococcus pyogenes samples. Cited in 13 publications.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Streptococcus pyogenes,
Applications:IP, IHC-P, IHC-Fr, ELISA, WB, Dot, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Streptococcus Pyogenes Group A

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Serum was collected and antibody to the Group A carbohydrate was immunoaffinity purified, Storage buffer-pH: 7.2Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Streptococcus pyogenes Group A Carbohydrate also known as Group A strep carbohydrate acts mechanically as an important component of the cell wall in Group A Streptococcus (GAS) providing structural integrity and mediating adherence to host tissues. It consists of a rhamnose-N-acetylglucosamine polysaccharide. The carbohydrate group mass primarily composed of rhamnose is not definitively measured but its structure plays a significant role in its function. GAS expresses this carbohydrate on its surface making it accessible for interaction with the host immune system.
Biological function summary
The carbohydrate group enables Streptococcus pyogenes to interact with host tissues and evade immune detection. It is recognized as an antigen prompting the immune response by generating specific antibodies such as antistrep and antigroup antibodies. As part of the cell wall capsule the Group A carbohydrate is important for maintaining the bacterial phenotype and survival within the host. This structural component does not act alone but is associated with other cell wall proteins and elements.
Pathways
The Group A Carbohydrate plays an important role in the pathogenesis and immune evasion strategies of Streptococcus pyogenes. It does not directly involve complex metabolic pathways but is vital in the adherence and colonization processes which are more of physical pathways within the host. Its interactions influence pathways related to the immune response. Other pathogenic proteins such as M protein known for interfering with phagocytosis are associated with Group A carbohydrate through these biological functions.
Group A Streptococcus is associated with infections such as pharyngitis and rheumatic fever. The Group A carbohydrate targets the immune system impacting how antibodies recognize and respond to GAS. Rheumatic fever connects with the carbohydrate due to the cross-reactivity of host antibodies against it. Proteins like the M protein also play a role in these diseases further complicating the host-pathogen interaction and contributing to the severity of infections.