Abcam, ab92515, Anti-Otx1 antibody [EPR3347]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal OTX1 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat, Recombinant full length protein - Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3347,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Otx1 also known as Orthodenticle homeobox 1 is a transcription factor with a noted molecular weight of approximately 32 kDa. It identifies as a homeodomain-containing protein that binds to specific DNA sequences regulating gene expression. This protein finds expression mainly in the developing and adult brain where it plays significant roles in brain morphogenesis. In addition to the central nervous system Otx1 displays expression in the retina and skeletal tissues during embryonic development.
Biological function summary
Otx1 functions in the regulation of several critical developmental processes. It contains a homeodomain which allows the protein to precisely bind to DNA influencing the transcriptional activation of target genes. Although it does not participate in large protein complexes it exerts influence in morphogenesis by its interaction with co-factors that regulate gene expression important for brain and sensory organ development. Its expression is pivotal in maintaining the balance of excitatory and inhibitory signals during cortical development.
Pathways
Otx1 integrates into signaling networks essential for developmental processes. It participates actively in pathways like the Wnt signaling pathway and the Sonic Hedgehog (Shh) pathway both contributing significantly to brain development and patterning. Within these pathways it interacts closely with proteins like β-catenin in the Wnt pathway and Gli transcription factors in the Shh pathway steering the developmental fates of neural progenitors.
Otx1 contributes to conditions affecting the central nervous system. Mutations or dysregulation of Otx1 have connections to intellectual disabilities and specific epilepsy forms due to its role in cortical neuron development and function. The protein's interactions with other developmental regulators such as Pax6 offer insights into congenital neural developmental disorders emphasizing its critical role alongside other homeodomain proteins in maintaining proper neural development and function.