Abcam, ab93616, Anti-Nav1.8/SCN10A antibody [S134]

Size: 20µg / 100µg / 1mg
Anti-Nav1.8/SCN10A antibody [S134] (ab93616) is a mouse monoclonal antibody detecting Nav1.8/SCN10A in IHC-P . Suitable for Mouse, Rat . - Trusted since 2010
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:S134,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat Scn10a aa 1700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q62968

Product details:
What is this antibody validated in?
Anti-Nav1.8/SCN10A antibody [S134] (ab93616) is a mouse recombinant monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Mouse, Rat samples.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nav1.8 also known as SCN10A is a voltage-gated sodium channel. It facilitates the rapid transit of sodium ions across cell membranes essential for the propagation of action potentials in neurons. Nav1.8 has a mass of approximately 220 kDa and it expresses primarily in peripheral sensory neurons including dorsal root ganglia. This channel is activated mainly in response to depolarization enabling the initiation and conduction of electrical signals.
Biological function summary
Nav1.8 contributes significantly to pain transmission especially in nociceptive neurons which detect painful stimuli. It operates as a principal component in generating sustained action potentials required for pain signal propagation. Nav1.8 is not a part of a larger complex but plays a standalone critical role. It shows high expression during inflammatory and neuropathic pain conditions indicating its role in pain pathways.
Pathways
Nav1.8 is involved in both the pain and neuroinflammatory pathways. It influences the activity of other sodium channels such as Nav1.7 another critical mediator of pain sensation. Pain pathways extensively integrate Nav1.8 function especially in the modulation of pain thresholds and states. Neuroinflammatory pathways utilize Nav1.8 to alter neuron excitability under inflammatory conditions which is significant for understanding different pain modalities.
Nav1.8 is associated with chronic pain disorders such as neuropathic pain and inflammatory pain conditions. Variations in Nav1.8 are linked to altered pain sensitivity and are researched as potential therapeutic targets for pain relief. In diseases like diabetic neuropathy Nav1.8 changes correlate with increased neuronal excitability and persistent pain sensation. Its relationship with proteins like Nav1.7 in these contexts highlights its importance in the diagnostic and therapeutic options for pain management.