Abcam, ab94506, Anti-beta 3 Adrenergic Receptor antibody

Size: 100µg
Anti-beta 3 Adrenergic Receptor antibody (ab94506) is a rabbit polyclonal antibody detecting beta 3 Adrenergic Receptor in Western Blot, IHC-P . Suitable for Mouse, Rat . - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Product details:
What is this antibody validated in?
Anti-beta 3 Adrenergic Receptor antibody (ab94506) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Mouse, Rat samples.
What is the molecular weight of beta 3 Adrenergic Receptor?
Anti-beta 3 Adrenergic Receptor (ab94506) specifically detects a band for beta 3 Adrenergic Receptor (UniProt: P13945) at a molecular weight of 43kDa.
Trusted by the scientific community
Anti-beta 3 Adrenergic Receptor (ab94506) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The beta 3 adrenergic receptor also known as beta-3 adrenoceptor or B3 adrenergic receptor is a member of the adrenergic receptor family that activates the GS protein upon binding ligands like catecholamines. This receptor approximately 408 amino acids in size has a predominant mass of around 45 kDa. It is mainly expressed in adipose tissue but also found in the gallbladder urinary bladder and the gastrointestinal tract. These receptors primarily mediate lipolysis and thermogenesis in brown adipose tissue through interaction with norepinephrine and epinephrine.
Biological function summary
The beta 3 adrenergic receptor plays an important role in energy expenditure and metabolic processes. It does not typically form part of a complex but interacts with GS proteins leading to the activation of adenylyl cyclase and consequent increase in cAMP levels. This receptor is instrumental in the regulation of lipid metabolism which aids in maintaining balance in energy store.
Pathways
The beta 3 adrenergic receptor is involved in the adrenergic signaling pathways regulating energy expenditure and thermogenesis. These pathways often work together with other adrenergic receptors such as beta 1 and beta 2 receptors. An important pathway involving the beta 3 adrenergic receptor is the cAMP-dependent pathway which influences metabolic functions and energy homeostasis in the body.
The beta 3 adrenergic receptor is associated with obesity and diabetes. Altered function or expression of this receptor can impact the body's ability to regulate energy metabolism leading to these metabolic disorders. The receptor's function has connections with insulin-like growth factor 1 (IGF1) as changes in energy metabolism affect insulin signaling and glucose homeostasis. Abnormal adrenergic receptor activity can also contribute to bladder disorders due to its expression in the urinary system.