Abcam, ab94805, Anti-Respiratory Syncytial Virus M2-1 Protein antibody [RSV5H5]

Size: 100µg
Anti-Respiratory Syncytial Virus M2-1 Protein antibody [RSV5H5] (ab94805) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus M2-1 Protein in Western Blot, IP, ICC/IF, ELISA . Suitable for Respiratory syncytial virus . - Trusted since 2010
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:RSV5H5,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Respiratory syncytial virus,
Applications:IP, ELISA, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody has broad specificity for Respiratory Syncytial Virus of both sub-groups A and B

Product details:
What is this antibody validated in?
Anti-Respiratory Syncytial Virus M2-1 Protein antibody [RSV5H5] (ab94805) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Respiratory syncytial virus samples.
Trusted by the scientific community
Anti-Respiratory Syncytial Virus M2-1 Protein [RSV5H5] (ab94805) was first used in a scientific publication in 2010 and has been cited over 10 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 99.98% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Respiratory Syncytial Virus M2-1 protein also known as RSV M2-1 is an essential component in the viral replication process. This protein has a mass of approximately 19 kDa and is primarily expressed in the infected host cells. M2-1 functions as an antiterminator during viral mRNA transcription allowing the virus to produce full-length mRNA transcripts. Its role is critical for the successful synthesis of viral proteins which are necessary for virus assembly and release.
Biological function summary
The Respiratory Syncytial Virus M2-1 protein interacts with the viral RNA polymerase complex. Its activity prevents premature termination ensuring the proper transcription of viral genes. The protein plays a significant role in the synthesis of viral RNA facilitating the transition from transcription initiation to elongation. M2-1 does not act alone; it forms part of a dynamic complex with other viral proteins such as the RSV L protein and its cofactor the P protein.
Pathways
The M2-1 protein is important in the replication and transcription pathway of the Respiratory Syncytial Virus. This pathway involves other viral proteins like N (nucleoprotein) and M (matrix protein) which help stabilize and protect the viral RNA aiding in the virus's lifecycle. M2-1 regulates the switch from RNA synthesis to genome replication integrating its mechanistic functions into the larger context of viral propagation and host cell interaction.
The M2-1 protein of the Respiratory Syncytial Virus plays a central role in the pathogenesis of respiratory infections. RSV is a major cause of severe respiratory tract infections particularly in infants and the elderly causing conditions such as bronchiolitis and pneumonia. The M2-1 protein's interaction with the viral L protein during RNA synthesis can be a target for antiviral strategies aimed at disrupting the virus's replication capabilities thereby reducing disease severity.