Abcam, ab95072, Anti-PYGO1 antibody

Size: 20µg / 100µL
Rabbit Polyclonal PYGO1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Pygopus homolog 1 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Pygopus homolog 1 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y3Y4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PYGO1 also known as Pygopus homolog 1 functions as a co-activator in Wnt signaling playing an important role in transcriptional activation. It comprises a protein mass of approximately 44 kDa. The expression of PYGO1 occurs in various human tissues with increased levels observed in the brain and testes. As a component of the β-catenin destruction complex PYGO1 influences the stabilization and nuclear localization of β-catenin which is essential for its activity.
Biological function summary
PYGOPUS 1 acts as a significant mediator in the Wnt/β-catenin signaling pathway primarily facilitating gene transcription by interacting with both β-catenin and other transcriptional co-activators. It belongs to a multi-protein complex that modulates chromatin remodeling and transcription. PYGO1 enhances the function of the TCF/LEF family of transcription factors impacting cell fate decisions during developmental processes.
Pathways
PYGO1 significantly impacts the Wnt signaling pathway which plays a critical role in embryonic development and cell proliferation. In collaboration with proteins like β-catenin and BCL9 PYGO1 aids in the regulation of target gene expression. Another important pathway involving PYGO1 is the Notch signaling pathway where it can indirectly influence cellular differentiation and apoptosis through cross-talk and interplay with Wnt pathways highlighting its integrative role in cellular signaling.
PYGO1 shows associations with cancer particularly colorectal cancer due to its role in aberrant Wnt signaling. Abnormal activation of the Wnt/β-catenin pathway where PYGO1 is actively involved contributes to tumorigenesis and cancer progression. Additionally in rheumatoid arthritis mutations or altered expressions of PYGO1 may influence inflammatory responses potentially in coordination with proteins such as β-catenin indicating its broader implication in inflammatory and autoimmune conditions.