Abcam, ab95954, Anti-Rab-6 antibody

Size: 50µL
Rabbit Polyclonal RAB6A antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RAB6A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RAB6A.P20340

Product details:
We have not tested the cross reactivity to RAB6B. ab95954 is raised against a full length RAB6A recombinant protein and may cross-react with RAB6B.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rab-6 also known as Ras-related protein 6 acts as a GTPase involved in membrane trafficking. This protein has a molecular mass of approximately 24 kDa. Researchers find Rab-6 expressed in various tissues with high levels in the brain and lungs. It localizes primarily to the Golgi apparatus where it participates in the regulation of intracellular transport.
Biological function summary
Rab-6 aids in the coordination of retrograde vesicle transport from the Golgi to the endoplasmic reticulum. Rab-6 functions as part of a complex with other proteins including dynactin and cytoplasmic dynein to facilitate these movements. Its role includes ensuring proper delivery and sorting of proteins within the cell which is essential for maintaining cellular organization and function.
Pathways
This protein is involved in the endocytosis and secretory pathways. In the endocytosis pathway Rab-6 interacts with proteins like Rab GDI and Rab escort protein to regulate vesicle transport. In the secretory pathway the protein ensures that cargo proteins transit correctly through the Golgi interacting with other Rab family members such as Rab-1 which also play parts in vesicle movement and secretion processes.
Rab-6 has been implicated in neurological disorders and certain cancers. For instance abnormalities in Rab-6 function have been linked to Alzheimer's disease where it associates with proteins like amyloid precursor protein affecting its processing. Additionally altered Rab-6 activity can contribute to cancer metastasis through interactions with metastasis-related proteins which influences cell migration and invasion mechanisms.