Abcam, ab96725, Anti-Coatomer subunit delta/COPD antibody

Size: 100µL
Rabbit Polyclonal Coatomer subunit delta/COPD antibody. Suitable for IHC-P, WB, ICC/IF, IHC-Fr and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARCN1 aa 50-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARCN1 aa 50-500. The exact immunogen used to generate this antibody is proprietary information.P48444

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Coatomer subunit delta also called COPD is a component of the COPI coatomer complex involved in membrane trafficking processes. This protein has a mass of approximately 50 kDa and is found in Golgi-associated transport systems. It interacts with other coatomer proteins to form a multi-subunit complex that assists in transporting molecules between Golgi compartments and from the Golgi to the endoplasmic reticulum. Its presence is typically noted in most eukaryotic cells contributing to its essential role in the cellular transport machinery.
Biological function summary
The coatomer subunit delta participates as a part of the COPI coatomer complex which is essential in vesicle formation. This complex stabilizes curvature in membranes to help form vesicles important for intracellular transport. It is key in the recycling of proteins and lipids to the endoplasmic reticulum maintaining homeostasis within the cell. The coatomer complex works with proteins such as ARF1 which activates the assembly of the coatomer complex onto membranes facilitating proper cargo selection and vesicle budding.
Pathways
The coatomer subunit delta is integral to vesicular trafficking pathways including the retrograde transport pathway from Golgi to the endoplasmic reticulum. It plays a significant role in the secretory pathway which is central to the transport of proteins and lipids. It has interactions with other coatomer subunits and accessory proteins ensuring efficient pathway function. It relates closely to proteins such as ARF1 and various cargo receptors which are essential for sorting and transport of cargo.
Improper functioning of the coatomer subunit delta can contribute to neurodegenerative conditions and certain types of cancer. Its disturbance may relate to Alzheimer’s disease where cellular transport mechanisms are disrupted leading to protein misfolding and aggregation. Additionally abnormalities in coatomer subunits are linked to some cancers potentially due to their influence on cell growth and proliferation. The interactions with proteins like ARF1 can amplify these effects highlighting the necessity of functional coatomer subunit delta for health maintenance.