Abcam, ab96727, Anti-DRAGON antibody

Size: 50µL
Rabbit Polyclonal DRAGON antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGM domain family member B aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RGM domain family member B aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6NW40

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DRAGON also known as Repulsive Guidance Molecule b (RGMb) is a glycoprotein involved in the regulation of signaling pathways. It weighs approximately 50 kDa and is widely expressed in various tissues including the central nervous system liver and developing limbs. As a prominent member of the RGM family DRAGON plays a part in critical cellular processes such as growth and differentiation although the detailed mechanical actions require further exploration.
Biological function summary
This protein is significant in iron metabolism and the bone morphogenetic protein (BMP) signaling pathway. It acts not only independently but also as part of a complex with the BMP receptors playing roles in embryogenesis and neurodevelopment. Its binding properties enable it to modulate BMP signals important in processes like bone formation and neural patterning.
Pathways
DRAGON interacts primarily within the BMP signaling pathway and the hepcidin pathway. By coupling with BMPs such as BMP-2 and BMP-6 DRAGON influences processes like cellular growth and apoptosis guide. Its participation in the hepcidin pathway impacts iron homeostasis as it potentially regulates hepcidin an essential hormone produced by the liver that governs iron absorption and distribution in the body. These interactions highlight DRAGON's role in coordinating complex biological activities alongside proteins like hemojuvelin and neogenin.
DRAGON's dysfunction links to conditions like anemia and cancer. Abnormalities in its expression or interaction may result in improper iron metabolism seen in anemia of chronic disease. Further its role in BMP signaling connects it to oncogenic processes contributing to tumor development in cancer. The interaction with other proteins such as BMPs and neogenin suggests that modulation of these pathways could present therapeutic avenues in diseases linked to DRAGON dysregulation.