Abcam, ab97458, Anti-AKR7A2 antibody

Size: 50µL
Rabbit Polyclonal AKR7A2 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AKR7A2 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AKR7A2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43488

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AKR7A2 also known as aflatoxin aldehyde reductase or succinic semialdehyde reductase is an enzyme with a molecular mass of approximately 38 kDa. It is part of the aldo-keto reductase superfamily and catalyzes the reduction of aldehydes and ketones to their corresponding alcohols using NAD(P)H as a cofactor. AKR7A2 is expressed in various tissues with significant levels in the liver kidney and lungs indicating its involvement in detoxification processes.
Biological function summary
AKR7A2 participates in the detoxification of harmful aldehydes and builds up resistance against oxidative stress. This enzymatic activity helps in converting reactive aldehydes which are formed during lipid peroxidation into less harmful compounds. AKR7A2 does not form part of a larger enzymatic complex but interacts with other molecules within the cell to fulfill its protective roles. By metabolizing these aldehydes AKR7A2 contributes to safeguarding cellular integrity and function.
Pathways
AKR7A2 is involved in cellular defense mechanisms and detoxification pathways. It plays a role in the glutathione metabolism pathway important for handling oxidative damage in cells. AKR7A2 also intersects with pathobiological pathways related to aldehyde detoxification. Its activity correlates with proteins such as glutathione S-transferases (GSTs) which together help neutralize and excrete toxic substances from the body maintaining cellular health.
AKR7A2 has links to cancer and neurodegenerative diseases. High levels of this enzyme are associated with increased capacity to detoxify carcinogenic aldehydes which could contribute to resistance against chemotherapy in certain cancers. Additionally alterations in AKR7A2 activity are seen in neurodegenerative disorders due to its pivotal role in protecting neurons from oxidative stress. Proteins like aldehyde dehydrogenases (ALDHs) also participate in these oxidative pathways and have connections with AKR7A2 in such disease contexts highlighting the enzyme's importance in disease prevention and progression.