Abcam, ab97588, Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2]

Size: 50µg
Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2] (ab97588) is a rat monoclonal antibody detecting Integrin alpha V + beta 6 in Flow Cytometry, ICC/IF, Neut . Suitable for Human . - Trusted since 2010
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:avB6 53a.2,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt, FuncS (Neut/Block)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Human ITGAV. The exact immunogen used to generate this antibody is proprietary information.P06756,
Epitope:Extracelllular region of the heterodimer.

Product details:
What is this antibody validated in?
Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2] (ab97588) is a rat monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF), Neutralising in Human samples.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin αvΒ6 also known as integrin alpha V beta 6 or integrin avb6 is a protein that plays a significant role in cellular adhesion and signaling. This heterodimeric complex consists of alpha V and beta 6 subunits with a molecular weight around 150 kDa. Integrin αvΒ6 is primarily expressed in epithelial cells and remains largely absent in normal tissues but becomes upregulated in activated or injured epithelial tissues. Due to its limited expression under normal conditions integrin αvΒ6 presents a notable interest for research in tissue repair and related processes.
Biological function summary
Integrin αvΒ6 engages in binding with specific ligands such as fibronectin vitronectin and latency-associated peptides. This protein forms a part of a larger integrin family existing as a heterodimer playing an important role in the activation of transforming growth factor-beta (TGF-Β). The interaction between integrin αvΒ6 and its ligands contributes to cell proliferation migration differentiation and modulation of the local cellular environment affecting tissue remodeling and immunity.
Pathways
Integrin αvΒ6 is involved in TGF-Β signaling and the epithelial-mesenchymal transition (EMT) pathway. These pathways are fundamental for regulating developmental processes and tissue repair providing cues for cell fate and homeostasis. Additionally integrin αvΒ6 associates with other proteins including fibronectin and vitronectin enhancing its role in mediating cell-extracellular matrix interactions which supports cellular communication and migration essential for these pathways.
Integrin αvΒ6 has been implicated in conditions like fibrosis and cancer. Its involvement in promoting EMT and activating TGF-Β connects it closely with fibrotic diseases such as idiopathic pulmonary fibrosis where tissue scarring results from excessive collagen deposition. Regarding cancer integrin αvΒ6 expression is often increased in tumors and contributes to tumor progression and metastasis particularly in pancreatic cancer. Integrin αvΒ6 often collaborates with proteins like TGF-Β which actively participate in pathways facilitating these disease processes.