Abcam, ab97603, Anti-ADAMTSL2 antibody

Size: 50µL
Rabbit Polyclonal ADAMTSL2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950. The exact immunogen used to generate this antibody is proprietary information.Q86TH1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAMTSL2 also known as ADAMTS-like 2 is a secreted glycoprotein that belongs to the family of ADAMTS-like proteins. The molecular mass of this protein is approximately 65 kDa. ADAMTSL2 expresses predominantly in connective tissues and various organs including the skin cartilage and lung tissues. It shares structural similarities with other members of the ADAMTS family but lacks the protease domain which is essential for proteolytic activity in related proteins.
Biological function summary
ADAMTSL2 plays an important role in extracellular matrix organization and assembly. It is not part of a known complex but it interacts closely with fibrillin-1 influencing the regulation of microfibril architecture. The presence of ADAMTSL2 can impact the deposition and maintenance of elastic fibers contributing significantly to the structural integrity of connective tissues.
Pathways
The presence of ADAMTSL2 is integral to the TGF-beta signaling pathway and extracellular matrix-receptor interaction pathway. It modulates the bioavailability of latent TGF-beta by interacting with fibrillin-1 and indirectly influencing the activity of proteins like LTBP4. These interactions play a role in maintaining proper tissue architecture and cellular functions by mediating signaling cascades essential for tissue repair and homeostasis.
Mutations in the ADAMTSL2 gene associate with geleophysic dysplasia a rare skeletal disorder characterized by short stature and heart valve abnormalities. The connection to fibrillin-1 further links ADAMTSL2 to disorders such as Marfan syndrome though through indirect pathways rather than direct genetic links. The involvement of other proteins in this process such as LTBP4 and fibrillin-1 helps elucidate the molecular mechanisms underlying these conditions.