Abcam, ab97818, Anti-TATDN1 antibody

Size: 50µL
Rabbit Polyclonal TATDN1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TATDN1 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TATDN1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q6P1N9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TATDN1 also known as TatD DNase domain-containing protein 1 functions mechanically as a deoxyribonuclease in eukaryotic cells. This protein has a mass of approximately 34 kDa and is expressed in various tissues including the heart skeletal muscle and testis. TATDN1's nuclease activity involves catalyzing the hydrolysis of phosphodiester bonds which is significant in DNA metabolism processes.
Biological function summary
TATDN1 participates in apoptosis wherein it promotes the degradation of nuclear DNA during cell death. TATDN1 associates with complexes involving DNA repair and maintenance indicating its role in maintaining genomic integrity. The protein's ability to localize in different cellular compartments suggests its involvement in multiple cellular processes further highlighting its functional versatility in cells.
Pathways
TATDN1 engages in processes linked to both DNA damage response and apoptosis. It operates within the apoptosis pathway interacting with proteins like caspases which are responsible for the execution phase of cell apoptosis. In the context of DNA repair pathways TATDN1 may associate with proteins involved in detecting and rectifying DNA strand irregularities linking it to a network that enhances cell survival under stress.
TATDN1 shows relevance in cancer and neurodegenerative diseases due to its roles in DNA repair and apoptosis. Aberrant regulation of TATDN1 has been implicated in cancer as its dysfunction could lead to unchecked cellular proliferation. Additionally in neurodegenerative diseases TATDN1's interactions with proteins such as p53 suggest its contribution to cellular malfunction and death aggravating disease progression.