Abcam, ab97889, Anti-C16orf62 antibody

Size: 50µL
Rabbit Polyclonal C16orf62 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VPS35L aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human VPS35L aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q7Z3J2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C16orf62 also known as Chromosome 16 Open Reading Frame 62 is a lesser-known but important protein with a predicted mass of approximately 40 kDa. These proteins are most notably expressed in tissues such as the pancreas and liver. While not widely studied it is thought that C16orf62 might contribute to processes that have not been fully elucidated yet. As research on this gene progresses a clearer understanding of its precise mechanical roles will likely emerge.
Biological function summary
C16orf62 plays an important role in cellular homeostasis and metabolic regulation. It is part of a multiprotein complex called the ER-associated degradation (ERAD) complex. Within this complex C16orf62 contributes to the detection and degradation of misfolded proteins maintaining protein quality control inside the cells. The balance achieved by C16orf62 and its complex partners is critical in preventing the accumulation of defective proteins that can lead to cellular stress and dysfunction.
Pathways
C16orf62's function as part of the ERAD complex integrates into the broader protein processing pathways in the endoplasmic reticulum. This regulation involves pathways like the ER stress response and the ubiquitin-proteasome system. C16orf62 collaborates with other proteins in these pathways such as ubiquitin ligases which tag misfolded proteins for degradation. These interactions emphasize its role in maintaining cellular protein homeostasis and adapting to stress conditions.
The misregulation of C16orf62 has implications for conditions like cystic fibrosis and certain liver diseases. In cystic fibrosis the improper degradation of misfolded proteins can exacerbate the disease pathogenesis. This protein functioning with partners like the CFTR protein highlights its potential connection to the disease mechanisms. Similarly in liver disorders defects in protein quality control pathways can lead to accumulation of toxic proteins contributing to disease progression. Understanding C16orf62's influence on these disorders could open new avenues for therapeutic approaches.