Abcam, ab97918, Anti-ASB9 antibody

Size: 50µL
Rabbit Polyclonal ASB9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ASB9 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ASB9 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96DX5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ASB9 known as Ankyrin Repeat and SOCS Box Protein 9 is a protein that serves significant roles in cellular processes. Its molecular weight is approximately 32 kDa. ASB9 is expressed mainly in kidney and heart tissues. The protein is part of the larger ankyrin repeat and suppressor of cytokine signaling box (SOCS box) protein family which interacts with components of the ubiquitin-proteasome pathway.
Biological function summary
ASB9 regulates protein degradation by modulating the ubiquitination process. It functions as part of an E3 ligase complex facilitating protein tagging for proteasomal degradation. The ubiquitination role of ASB9 affects various substrates within cells modulating processes such as degradation and turnover of proteins therefore controlling cellular homeostasis and responses. This modulatory influence is particularly relevant in cellular stress conditions where precise control of protein levels is necessary.
Pathways
ASB9 plays roles in the ubiquitin-proteasome system and cellular stress response pathways. It interacts within the protein degradation pathways to ensure removal of misfolded or damaged proteins. ASB9 connects with Cullin-RING ubiquitin ligases within this system. Additionally collaborations between ASB9 and heat shock proteins are important for maintaining protein homeostasis contributing to cellular recovery during stress events.
ASB9 has relevance in cardiac and renal dysfunctions. Variations in ASB9 expression or function can perturb proteostasis potentially contributing to heart failure and kidney disease. In the context of heart failure ASB9 may interact with proteins like alpha-actinin influencing cardiac muscle function. For kidney disorders changes in ASB9 levels might alter cellular signaling impacting processes critical for kidney health and filtration function.