Abcam, ab99382, Anti-ARAP1 antibody

Size: 100µg
Rabbit Polyclonal ARAP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ARAP1 aa 1150-1250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ARAP1 aa 1150-1250. The exact immunogen used to generate this antibody is proprietary information.Q96P48

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ARAP1 protein also known as Centaurin delta-1 plays a role in mechanics acting as an ArfGAP with RhoGAP domain and Ankyrin repeat protein. ARAP1 weighs approximately 150 kDa and mainly expresses in tissues including the heart liver and skeletal muscle. This protein localizes primarily in the cytoplasm and is involved in cellular processes by regulating phosphoinositide 3-kinase (PI3K) signaling.
Biological function summary
ARAP1 coordinates the remodeling of the actin cytoskeleton. It assists in cell adhesion migration and endocytosis. Through its GAP domains ARAP1 regulates small GTPases such as Arf and Rho proteins which participate in vesicular trafficking and cytoskeletal dynamics. While not a member of a specific complex it interacts with signaling molecules to influence cellular shape and movement.
Pathways
ARAP1 acts in the PI3K/AKT and Rho signaling pathways shaping cellular responses to external stimuli. It regulates the localization and activity of phosphoinositide phosphates important for the PI3K/AKT pathway. ARAP1's interaction with proteins like Akt and RhoA affects their signaling to produce changes in cell motility and growth integrating signals from various upstream activators.
ARAP1 has links to cancer and type 2 diabetes. In cancer ARAP1 may contribute to tumor cell invasiveness relating to its function in actin cytoskeleton regulation and its interaction with RhoA. Additionally its association with PI3K/AKT pathway dysregulation connects ARAP1 to insulin signaling disruption relevant in type 2 diabetes. Understanding these interactions may provide insights into therapeutic strategies.