Agilent, GK80115, Extender kit for complex O-linked glycans

Extender kit for complex O-linked glycans. Contains enzymes needed to remove complex O-linked carbohydrates from glycosylated glycoproteins when used with GK80110. For notes on use, please see the GK80110 Instruction Manual. Enzymes are also available separately as β(1-4)-Galactosidase (GKX-5014) and β N-Acetylhexosaminidase (GK80050).

Specifications:
Application: Bioactivity in O-glycans
Enzyme Applications: Control glycoprotein providedDeglycosylates up to 2 mg of glycoproteinNative & denaturing protocolsNo degradation of proteinRemoves O-linked sugars containing polysialic acid

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The Extender kit for complex O-linked glycans is designed to streamline and enhance the analysis of highly branched and diverse O-glycan structures. This specialized kit enables efficient preparation and extension of O-linked glycans from glycoprotein samples, making it especially valuable in glycomics research, biomarker discovery, and biopharmaceutical characterization. By facilitating the selective addition and modification of glycan structures, it supports researchers in elucidating glycosylation patterns relevant to cellular processes and disease mechanisms.

The kit includes optimized reagents and protocols to improve glycan chain extension and labeling, ensuring high sensitivity and reproducibility in downstream analysis. It is ideal for use in workflows aimed at detailed structural elucidation of complex O-linked glycans using mass spectrometry, HPLC, or capillary electrophoresis platforms. Compatible with a range of Agilent analytical instruments such as LC and CE systems, as well as glycan analysis software, this kit fits seamlessly into existing laboratory setups. For extended capabilities, it can be used alongside Agilent glycan labeling and quantitation kits, offering a flexible solution tailored to advanced glycomics applications. This all-in-one kit is an essential tool for laboratories focused on comprehensive O-glycan profiling and characterization.